Mallo, M. J., Goji, S. Z. and Istifanus, E. F.

• access_time13 April, 2024

  subjectCategory: Physiology

• The aim of this study was to determine the effect of oral administration of aloe vera extract on kidney functions and haematological parameters in Wistar rats. Twenty adult male albino rats weighing between 150g – 200g were used for the study. They were randomly divided into four groups, namely. Group I (control), II, III and IV were administered 50, 100 and 150mg/kg aloe vera extract respectively for 21 days. Blood samples (2ml), were obtained by cardiac puncture into EDTA bottles to determine; Red blood cells, White blood cells, Haemoglobin, Mean cell volume, Mean cell haemoglobin, Mean cell haemoglobin concentration and Platelets. Another 2ml were collected into plain sample bottles without anticoagulant to determine; Blood urea nitrogen, Creatinine, Total protein and Serum albumin. Data obtained were subjected to analysis of variance using SPSS version 20 and Microsoft 2019 to plot graphs of means. The results obtained revealed that oral administration of aloe vera extract to Wistar rats significantly increased (p<0.05) RBC and MCHC in rats. RBC values obtained were 8.09 ± 0.20 x 1012/L in group 2 (50mg/kg aloe vera extract), 7.91 ± 0.27 x 1012/L in group 3 (100mg/kg aloe vera extract) and 7.54 ± 0.22 x 1012/L in group 4 (150mg/kg aloe vera extract). WBC, PCV, MCH, MCV did not vary significantly (p>0.05) from those of the control group. In conclusion, oral administration of aloe vera extract up to 150mg/kg body weight did not have any compromising effect on the haematological and Kidney function indices in Wistar rats.
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